Having a brand new installation running with Lion for a few weeks now on my new production machine and it’s running like a dream. Just installed the OS X update to 10.7.1, rebooted and had my fingers crossed as I had not rebooted the machine yet. After the reboot did a bunch of checks and everything was running fine. Indicating that the upgrade does not have any impact on our new setup (as was the intention of moving everything into /usr/local) which is great but also indicated that my installation from scratch went find as well and I had not missed any startup- script.

So feel free to upgrade and keep me posted of any issues you might find.